Forest plots illustrating how the individual studies contribute to the first meta-analysis in Table 1 (outcome: lifetime depression diagnosis; stress: exposure to childhood maltreatment) are shown in Figure 1. The protective effect of being male (Figure 1A) and the risk from stress (Figure 1B) are consistent across the individual studies, and correspond to overall p-values of 1.4E–15 and 1.7E–8, respectively. The lack of a main effect for the genetic variant in this model is also consistent across the studies (Figure 1C). For the interaction terms (childhood maltreatment exposure by number of S alleles) (Figure 1D), the point estimates are scattered on both sides of 1, and correspond to an overall p-value of 0.49.
