In this study, we utilized the NSDUH to answer three questions: (1) How have marijuana attitudes and marijuana-use-related outcomes changed across time from 2003-4 to 2010-11 within Colorado? (2) Considering these same variables, did Colorado differ from 34 states without medical marijuana laws in years 2003-4, 2005-6, 2007-8, 2009-10 and 2010-11? (3) Do trends in Colorado between 2006-8 and 2009-11 differ from those seen in non-medical marijuana states (NMMS) for the same time periods while adjusting for demographic differences?