Our findings with rs588765 and smoking abstinence in African American smokers are very similar to previous findings in Caucasian smokers (20). Both studies observed that the ‘T’ allele of rs588765 was associated with lower abstinence in the placebo group and higher abstinence when receiving nicotine replacement therapy (with significant interactions). However, the association between rs588765 and smoking abstinence was still observed at 6-month follow up in Caucasians, but not in African American smokers. This could be partially due to the relatively low smoking abstinence rates in African American smokers at 6-month follow up compared with the Caucasian smokers.
