Chunk #21 — Materials and methods — In silico functional follow up of associated SNVs

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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

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To identify whether the (replicated) SNVs identified here affected other traits, we queried the GWAS Catalog [38] (version: e91/28/02/2018, downloaded on 01/03/18) for genome-wide significant (P < 5 × 10−8) associations using all proxy SNVs (r2 ≥ 0.8) within 2 Mb of the top variant in our study.