10−13 (Table 2). Furthermore, correlation between rs2334499 and methylation of CpG-1 through CpG-5 was significant. For all five CpGs the T2D risk allele correlated with decreased methylation and this effect was observed regardless of whether the allele was inherited from the father or the mother. By contrast, neither the breast cancer variant nor the two other T2D markers at 11p15.5 showed any correlation with the methylation status of this CTCF site.
