to directly relate psychological and experiential factors to any known type of neuropathology. It is interesting that we have only identified genetic risk factors associated with AD pathology, and an ongoing genome-wide association study is examining additional genomic variants associated with cognitive decline and neuropathologic indices [148]. These observations have led us to consider a model whereby AD pathology is primarily under the control of genomic variation, whereas experiential and psychological factors primarily affect how the brain responds to the accumulation of pathology, i.e., neural or cognitive reserve. These findings are similar to results found in the Religious Orders Study [233–236].
