that one consequence of the A112G knockin mouse (and the A118G SNP) is the deletion of an N-linked glycosylation site. Glycosylation plays a role in receptor sorting, expression, trafficking, ligand binding, and signal transduction (Fan et al., 1997; Rathz et al., 2002; Zhang et al., 2001); alterations in these processes could affect MOPR function in ways distinct from protein level changes.
