Cannabis dependence accounted for 0.07% (0.05-0.1%) of global DALYs in 1990 and 0.08% (0.05—0.12%) in 2010. Although there was no change in the estimated contribution of cannabis dependence to global DALYs, there was an increase in crude DALYs across this period that was attributable to a 25% increase in population, a 6% decrease due to population ageing and a 1% increase in the prevalence rate of cannabis dependence. The net effect was a 22% increase in DALYs attributable to cannabis dependence between 1990 and 2010.