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Chunk #29 — Introduction — 6. Epigenome dynamics reveal enhancer modules and their putative regulators

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Integrative analysis of 111 reference human epigenomes.
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strong consistency with the known biology of the corresponding tissues. For example, stem-cell enhancers are enriched near developmental patterning genes, immune cell enhancers near immune response genes, and brain enhancers near learning and memory genes (Fig. 7b). Sub-clustering of individual modules continued to reveal distinct enrichment patterns of individual sub-modules (Fig. S11e), suggesting increased diversity of regulatory processes beyond the 226 modules used here.