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Chunk #12 — Methods — Image acquisition and DTI quantification

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Neurocognitive correlates of white matter quality in adolescent substance users.
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Data were corrected for motion, eddy current, and field distortions using FMRIB Software Library (FSL; Oxford, United Kingdom; (Smith et al., 2004)). Corrected images were subjected to tensor decomposition to derive scalar diffusion indices, FA and MD (Le Bihan et al., 2001). Computations were performed in native coordinate space using Analysis of Functional NeuroImages' (Cox, 1996) diffusion plug-in 3dDWItoDT (Cox & Glen, 2006). FA and MD were examined with whole-brain voxelwise analysis using Tract-Based Spatial Statistics (TBSS; (Smith et al., 2006)).