initiation of cell cycle arrest during damage repair or apoptosis if the damage cannot be repaired implies the existence of mechanisms for suppressing these pathways upon the completion of repair to allow the resumption of normal cell cycle progression. The Wild-type p53 inducible protein 1 (Wip1) phosphatase, the product of the PPM1D gene, plays an important role in the latter process. In other words, Wip1 dampens stress signaling and facilitates the return of the cell to a homeostatic state once the damage is repaired.
