(2004) showed that maximum similarity between additive QTL effects and the correlation between a molecular marker and a strain behavioral or neuronal phenotype is achieved either when heritability approaches unity or within-strain sample sizes are infinite. At a heritability of 0.30 and a within-strain sample size of 20, QTL detection is precise and reliable with a correlation of 0.97 between a molecular marker and a behavioral phenotype. Additional power and precision can be obtained by increasing the number of strains tested as the expanded set continues toward completed inbreeding.
