A greater capacity for emotion regulation has also been related to stress resilience, and studies of individuals with psychiatric disorders suggest that they have abnormalities in their emotion regulation systems5,99. A neural model of emotion regulation consisting of ventral and dorsal systems has been described, with various patterns of abnormalities associated with a range of psychiatric disorders100,101. Studies in mood and anxiety disorders have most consistently identified abnormalities in amygdala, hippocampus, subgenual ACC and PFC function102.