and 123,851 respectively. Chromosome (Chr) and position (Pos) for hg19 build 37. EA effect allele, OA other allele, Gene closest gene, N number of individuals, EAF effect allele frequency in the pooled samples, MAC minor allele count, DoE direction of effect, SE standard error. All SNVs had heterogeneity P > 0.02 in the discovery stage. *Replication was sought in 1,437 individuals of African American-ancestry from the HRS and COGA studies; **The beta(se) for the association of rs1190736 with PY in the replication stage was −0.026 (0.0039)Table 2Association results for novel SNVs identified in the combined meta-analysis of the discovery and replication cohortsdbSNP ID (Exome-chip ID)Chr:PosEA/OAGeneConsequenceTraitEAFBeta (se) in replication stageP-value in combined meta-analysis(P-value in Discovery/Replication stage)NotesCombining only genotyped Exome-chip content on the Axiom arrayrs15141751:74991644G/ATNNI3KIntronicSI0.57−0.011 (0.003)5.42 × 10−9 (9.03 x 10−5/1.0 x 10−5)Previously associated with BMIrs709616910:104618695G/ABORCS7(CNNM2# in Table 1)IntronicSI0.310.016 (0.003)2.17 × 10−13 (3.38 × 10−7/7.3 × 10−9)r2 = 0.28 between rs7096169 and rs12780116 (Table 1) in 1000 Genomes EUR. Previously associated with Schizophrenia. rs7096169 an eQTL for ARL3, BORCS7, and AS3MT in ≥1 of the brain tissues in GTExrs229223912:56482180G/TERBB3IntronicSI0.660.0121 (0.003)2.78 × 10−8 (7.56 × 10−5/1.5 × 10−5)Previously associated with type-1 diabetes and years of educational attainment. rs2292239 is an eQTL for RPS26
