Chunk #28 — Results — Mitochondrial damage and increased oxidative stress observed in SZ hiPSC NPCs

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Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia.

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In conditions of ROS, the oxidative modification of proteins introduces carbonyl groups (aldehydes and ketones) at Lys, Arg, Pro or Thr amino-acid residues. An OxyBlot assay revealed more ROS-induced oxidized proteins in the SZ hiPSC NPCs (Figure 4c).