Interview participants’ reflections on effective team processes for TD team science speak to the importance of team level factors in TD team science, as identified in the literature [6,21,45]. They described specific activities they engaged in to build mutual understanding, in particular, which can serve as helpful examples to other investigators embarking upon or engaged in TD team science. Their reports of the importance of brokering and bridge building activities by individuals in particular roles in a TD research center reinforce recent network analyses conducted by the NCI that also provide evidence for the importance of network brokers in facilitating TD collaborations within and across centers [46].