detected by Church et al.(41) in current smokers. In mutually adjusted analysis of cotinine and CPD, the association of cotinine with risk was considerably less attenuated than that of CPD. This is consistent with the notion that circulating cotinine captures other aspects of smoking behavior and dose than does CPD, such as inhalation depth and the degree to which each cigarette is smoked. However, the association of CPD remains substantial, suggesting that unlike circulating cotinine it has value for capturing past smoking behavior.
