same household as the proband were asked to participate in the study. The CADD is currently in its 3rd wave of data collection. For the current study, data collected during wave 2 were included in the analysis. If the subjects were not assessed at wave 2 data from wave 1 were included. Substance use was assessed with the Composite International Diagnostic Interview-Substance Abuse Module (CIDI-SAM; Cottler & Keating 1990). Individuals were also assessed for psychopathologies (e.g. depression, anxiety, antisocial personality disorder) using the Diagnostic Interview Schedule for DSM-IV (DIS; Robins et al. 2000). At wave 2, 27% of the control population met criteria for lifetime major depression, 8% for generalized anxiety and 29% for antisocial personality disorder compared to 33%, 15% and 67% in the clinical population, respectively. At the time of assessment, buccal cell DNA was collected from subjects on a voluntary basis. All recruiting, assessment, and DNA collection procedures were approved by the University of Colorado’s IRB. For analysis, genotypic data from all available family members were included, but the phenotypic data were limited to the offspring generation (probands, siblings, half-siblings, cousins, adopted siblings that were less than 35 years old at the time of assessment). Table 1
