Our results provide preliminary evidence that LECN functional connectivity may be weaker in OUD subjects compared to HC subjects. Differences in LECN resting state fMRI functional connectivity have been shown in cocaine use disorder and alcohol use disorder subjects relative to controls, but to our knowledge, this is the first published study to show differences in LECN resting state fMRI functional connectivity in OUD relative to HC [39–41]. These results need to be replicated, but if LECN functional connectivity can be shown to consistently differ in OUD subjects compared to HC, it may represent a neurobiological underpinning of impaired executive functioning observed in OUD [42]. Future studies should examine the association between LECN functional connectivity and addiction-related behaviors and treatment response in OUD.
