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Chunk #41 — Discussion — Limitations

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The structure of genetic and environmental risk factors for syndromal and subsyndromal common DSM-IV axis I and all axis II disorders.
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Fourth, we were unable to test, using standard twin model fitting, whether the addition of shared environmental factors would improve the fit of this large multivariate model. However, a wide range of previous analyses with most of the disorders included in our model failed to find evidence for substantial shared environmental effects (17–19, 27, 47, 49–52, 54). Furthermore, treating the criterion counts and subthreshold and threshold diagnoses as normally distributed, we compared the full model and a model that dropped all of the shared environmental parameters. It fitted much better using the Bayesian information criterion and also was clearly superior to a model that dropped all the additive genetic parameters. While we cannot rule out a modest degree of confounding of genetic with shared environmental effects, it is unlikely that this confounding is substantial.