With a combined test for admixture and association for the real DBP phenotype data and using an empirical significance threshold to adjust for multiple testing, Yorgov et al. [2013] identified a significant association with SNP rs12639065, located in an intergenic region between the LSM3 and SLC6A genes on chromosome 3. No significant SNPs were identified with the admixture mapping test, the association test, and the association test with adjustment for admixture for the DBP and SBP phenotypes. The authors additionally used simulated data sets for a trait not influenced by the genotype and verified that their method has the appropriate type I error rates. Yorgov et al. [2013] concluded from their analyses that combining admixture and association mapping signals is a promising approach for identifying variants for complex traits.
