Chunk #60 — STAR★METHODS — METHOD DETAILS — Burden Analyses — Estimation of Mutation Rate per BP

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De Novo Coding Variants Are Strongly Associated with Tourette Disorder.

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Alternatively, we can estimate an overall rate per bp as the number of de novo variants of a particular class observed cohort-wide divided by the number of callable bp assessed cohort-wide. These mutation rates were very similar to the mean rates estimated per bp (Table S3).