without any prior effect. GWAS3D also provides flexible configurations, such as human population, cell type specificity and TF family classification, for users to deal with different aspects of complex disease/trait. For example, user may select a matched cell type/tissue satisfying with a specific phenotype or manually define motifs of interested TFs used in following scanning when considering the tissue specificity of TFs. Recently, researchers found that the disease/trait-associated variants are highly related to active chromatin marks in relevant cell types (22). Therefore, these distinct features will greatly facilitate the discovery of regulatory variants under particular condition.
