To be included in the study, participants had to be Mission Indian, at least 1/16th Native American Heritage (NAH), between the age of 18 and 70 years, and be mobile enough to be transported from his or her home to the General Clinical Research Center (GCRC) of The Scripps Research Institute (TSRI). The protocol for the study was approved by the Institutional Review Board (IRB) of TSRI, the Scientific Advisory Committee of the GCRC, and the Indian Health Council, a tribal review group overseeing health issues for the reservations where recruitment was undertaken.
