In conclusion, we and others have shown that resting EEG power is heritable and as discussed above, numerous genes are likely to contribute to variation in EEG power. So far, only one published study [25] has identified a gene (GABRA2) that may influence EEG power. Our linkage scan identified CRH-BP as a strong candidate gene and we subsequently showed that CRH-BP is associated with alpha power, AUD and anxiety disorders in two ethnically diverse populations. Further work needs to be done to identify functional loci for GABRA2 and CRH-BP. Here, the use of a large family in an American Indian population isolate may have been important to identify linkage for a trait which may show high genetic heterogeneity. In terms of cross population validation, it is therefore of interest that our results were replicable in Caucasians.
