Table 2 provides four evaluations for each historical candidate gene for schizophrenia. The first evaluation is a meta-analysis of candidate gene association studies in SZGene published in 2008 or earlier showing the most-studied genetic marker per gene (Table S1 shows results for all markers). We have previously shown that the candidate gene studies in SZGene had small samples and poor coverage of common genetic variation.16 No finding is near genome-wide significance 15 (P<5x10−8), and all P-values for this evaluation fall short by a factor of 10,000 or more. None is notable even on a gene-wise basis (which many would consider inappropriately liberal).
