Two GWAS demonstrated 8q24 variation to be associated with prostate cancer risk [Freedman et al., 2006; Amundadottir et al., 2006; Yeager et al., 2007]. Eeles et al. [2008] conducted a GWAS to identify common alleles associated with prostate cancer. In the discovery stage, they studied 569,243 SNPs on 1,854 prostate cancer cases and 1,894 controls recruited through national studies in UK. Of the 53 SNPs significant at the P < 10−6 level, 20 SNPs were on 8q24, and six were on chromosome 17, regions previously shown to harbor loci associated with prostate cancer susceptibility [Eeles et al., 2008]. The remaining 27 SNPs were located in eight genomic regions. They evaluated 11 SNPs in a replication stage comprising 3,268 prostate cancer cases and 3,366 controls from studies in UK and Australia [Eeles et al., 2008]. After bias correction, we find that although the corrected OR estimates are smaller than the uncorrected OR, most of them are still larger than the OR estimates from the replication study. Of the 11 SNPs, 10 selection-adjusted CIs are consistent with those from the replication estimates
