There are no published GWAS studies of African ancestry populations with GWS results. We used GWAS to identify genetic variants that influence risk of AD as both a diagnosis and an ordinal trait in European-American (EA) and African-American (AA) subjects, including our GWAS sample of 5641 subjects combined with the study of addiction: genetics and environment (SAGE) sample of 4061, which is available to researchers through dbGAP application. Results for the diagnosis were replicated in two additional samples: an identically ascertained sample that we collected and a German sample collected previously.9 The ordinal trait results were replicated in our own additional subjects. The total sample (16 087 subjects) included the following: 5697 (GWAS discovery), 2545 (our identically ascertained replication sample), 3784 (German sample) and 4061 (SAGE, included with our samples for GWAS). Of these, there have been no previous reports regarding alcohol dependence GWAS in the first two sets, comprising 8242 subjects.
