Genetic mapping of intermediate phenotypes is not yet sufficiently advanced to know whether in general they have greater biological coherence, at a gene level, than psychiatric disease. The few results for brain morphometry hint at relevant biology — HRK acts as a regulator of apoptosis [60], FBXW8 has a known role in promotion of dendrite growth in hippocampal [61], SBNO1 is involved in Notch signaling [62] — but these results have not be been subject to the detailed pathway and functional analyses that might indicate mechanisms [63]. Currently it is unknown whether the interpretation of mapping intermediate phenotypes will prove easier than the interpretation of mapping disease phenotypes.
