In the present study, we calculated two independent polygenic risk profiles for alcohol dependence in 9863 members of Generation Scotland: Scottish Family Health Study (GS:SFHS), a population‐based epidemiological cohort (Smith et al. 2006). Two PGRS were created using summary data from two independent European‐American GWAS of alcohol dependence (SAGE, n = 2750; Yale‐Penn, n = 2377) (Gelernter et al. 2013). The GWAS summary data were meta‐analysed and a third PGRS created from the meta‐analysis data. The Yale‐Penn and SAGE datasets are the discovery samples from which GWAS summary statistics were derived and GS:SFHS is the sample in which PGRS were created and analysed. Alcohol dependence was not measured in GS:SFHS individuals and therefore polygenic risk profiles were used to explore the genetic relationship between alcohol dependence, cognitive ability, education and social deprivation.
