Twenty six adult male out-bred Sprague-Dawley rats (Charles River, QC), weighing 225–250g at the beginning of the experiment, were singly housed and maintained on a reverse light/dark cycle (8:00 hour lights off; 20:00 hour lights on) with free access to food and water except during behavioral testing, which occurred during the dark cycle. All experiments were approved by the Animal Care Committee of the University of Guelph and were carried out in accordance with the recommendations of the Canadian Council on Animal Care.
