Chunk #14 — Results — Oxidative stress exacerbated schizophrenia-like behavioral phenotypes

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Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

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The KO mice regardless of housing conditions showed novelty-induced hyperlocomotion at 8 weeks of age in the first three minutes of spontaneous exploration in the open field test (Figure 2C). Like PPI, this effect was not rescued by APO treatment.