LDSC revealed significant genetic correlations (FDR q<0.05) with 238 of nearly 1800 traits (Figure 3; Supplementary Table 6). The most significant observed correlations (Supplementary Table 3 shows all results at FDR q <0.05) were with respect to smoking and alcohol-drinking traits, where the top correlations were with current smoking status (positive correlation, rg= 0.55, p=1.30×10−39), the degree of past smoking (past tobacco smoking; negative correlation, rg= −.46, p=5.49×10−36) and “healthy” alcohol-drinking behaviors (e.g., alcohol usually taken with meals; negative correlation, rg= −.50, p= 5.44×10−34). Among the other highly significant correlations, several were related to level of education (e.g. years of schooling, rg= −.37 p=1.53×10−25) and socio-economic status (Townsend deprivation index, rg= 0.53, p=3.69×10−27). Numerous correlations were also found with measures of physical activity (e.g., no physical activity in the last four weeks, rg=0.41, p=3.06×10−17). Other noteworthy correlations included mood swings (rg=0.20, p=1.05×10−5) and risk taking (rg=.20, p=2.74×10−5). Considering psychiatric traits, we observed significant genetic correlations with depressive symptoms (rg = 0.22, p=4×10−4), schizophrenia (rg = 0.13, p=0×10−4), and attention deficit hyperactivity disorder (rg = 0.32, p = 0.023).
