The three search methods yielded a total of 554 unique published articles,1 the abstracts of which were screened for relevance (e.g., human subjects, alcohol-challenge design). Each of the 101 potentially relevant articles was obtained and coded by at least two trained, independent coders. Conflicts between coders were resolved by the coders and first author through consensus after additional examination of the articles. Coders examined each study using the following inclusion criteria: (a) the study described a lab-based alcohol-challenge study with human participants, (b) participants received a dose of alcohol which brought all participants to the same blood alcohol concentration (BAC), (c) participants consumed alcohol orally and were not maintained at a stable BAC (i.e., participants’ BACs were allowed to descend naturally), (d) participants self-reported their subjective response to alcohol, and (e) risk for alcohol use disorders (AUDs) was assessed as a function of FH or typical alcohol consumption.
