The 95% confidence interval for the genetic correlation between alcohol use frequency in adolescence and adulthood was distinct from one (rG= −.34, 95% CI [−1.61, 0.93]), suggesting that there is heterogeneity in the genetic liability that underlies alcohol use frequency throughout development. Notably, all estimates of H2SNP were small and non-significant (Adolescence H2SNP = .04, SE=0.04; Early Adulthood H2SNP = .05, SE = 0.05; Adulthood H2SNP = .08, SE = 0.04), indicating that the genetic correlations reported here account for only a small proportion of the overall relationship between these measures. Small estimates of H2SNP and the large confidence intervals for each genetic correlation indicate that these results should be interpreted with caution.
