Chunk #30 — Results — Simulations to demonstrate effectiveness of control over stratification in mixed population and family-based samples

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Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies.

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To simulate the marker information for the unrelated case–control data we use the Balding–Nichols model [34]. We generate samples from C subpopulations with a fixed Fst to model the difference in allele frequencies between populations. Trios are also generated from each of the C populations.