and lies within a childhood-onset OCD linkage peak.22 Similarly, the expression of DHRS11 (MGC4172) is strongly correlated (0.847, rank 25 of 22,328 transcripts) with that of FAIM2, which is located in the same LD block as the best SNP (rs297941) in the trio-case-control, and fifth best in the case-control meta-analyses. FAIM2 has been associated with neuroprotection following transient brain ischemia.68 The rat homologue of FAIM2, neural membrane protein 35 (NMP35), is expressed at the post-synaptic membrane in a subset of synapses and in dendrites, and co-localizes with the glutamate receptor GluR2.61 Thus, there is a potential relationship between rs6131295 (trio analysis), and FAIM2 and ADCY8 (tagged by the SNPs ranked numbers 1 and 7 in the trio-case-control analysis).
