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Chunk #21 — Results — Candidate SNP Analysis

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ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
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Only rs10774610 was present in our sample and itis associated with AD (p = 1.8×10-5), maximum drinks (p = 1.7×10-9), and flushing response (p = 7.5×10-15). When the ALDH2 SNP, rs671, is included as a covariate in the measured genotype association model, the association between rs10774610 and maximum drinks is nominally significant (p = 0.014) as is the association with flushing (p = 0.035).