All the patients underwent a full physical and neurological examination, routine blood analysis, brain CT or MRI scan as well as cognitive screening. The cognitive screening included MMSE, Addenbrooke’s Cognitive Examination (ACE), and Digit Symbol Substitution Test (DSST), including Clinical Dementia Rating (CDR). In addition, the patients and the relatives underwent NeuroPsychiatric Inventory (NPI), Major Depression Inventory (MDI), and Activities of Daily Living Inventory (ADCS-ADL). All CT and MRI scans were examined by a neuro-radiologist. Except for two patients with MCI and six HC, all patients had a lumbar puncture performed. If it was considered relevant for the diagnostic evaluation, the patients underwent a neuropsychological evaluation by a clinical neuropsychologist. Diagnoses were settled by consensus of a multidisciplinary team based on all examination results. The included MCI patients fulfilled the Winblad consensus criteria (Winblad et al., 2004) and the AD patients fulfilled the NIA-AA criteria (McKhann et al., 2011).
