Significant positive correlations between neutral-state anxiety levels and corticotropin and cortisol levels in each of the stress, cue, and neutral, relaxing conditions were also observed. These data are consistent with the notion of higher allostatic load in subjective, neuroendocrine, and motivational aspects of stress, anxiety, and craving processes during early alcohol recovery3,41,42 and that such increased load contributes to relapse processes and poor treatment outcome.3,10
