of the findings from both family- and population-based approaches, which provide convergent validation of the association findings. Finally, the issue of cumulative multiple testing needs to be considered, because many of our samples (our family samples and SCID-III-R or SCID-IV evaluated case-control samples) have been employed in previous studies. It is unclear how this should be addressed; we believe that it would be too stringent to correct the association results obtained in this study by the number of tested genes to date plus the number of tested markers in each gene; markers with minor or moderate effects would be neglected.
