Chunk #30 — Discussion

Source

Genome- and transcriptome-wide splicing associations with alcohol use disorder.

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Our exploratory study hypothesized that (1) polygenic scores of AUD would be higher in those with AUD than controls, (2) individual SNPs would be associated with abnormal alternative mRNA splicing in the brain, and (3) DNA variants around differentially spliced genes would contribute to the heritability of AUD.