The three CNR1 SNPs implicated in our study (i.e. rs7766029, rs12720071, and rs9450898) are localized to introns or within the untranslated region of Exon 4. No studies to-date has directly examined how these 3 SNPs may mediate CNR1 gene expression and function. There have not been genetic association studies linking these 3 SNPs to schizophrenia or to marijuana misuse either. Thus, the impact of these 3 SNPs on the pathophysiology of schizophrenia remains unknown. Nevertheless, previous studies have identified regulatory regions within cnr1/CNR1 (Borner, Bedini, Hollt, & Kraus, 2008; Zhang et al., 2004) that may provide useful indicators regarding the potential functional roles of rs9450898 and rs12720071 in mediating the neurobiology of schizophrenia. Based on the HapMap CEU population SNP database (http://www.hapmap.org), rs9450898 is in perfect LD with another CNR1 SNP rs2023239 (D′=1.0; r2=1.0). The latter has been associated with altered CNR1 Exon 3 RNA levels in the human brain (Zhang et al., 2004) as well as with prefrontal CB1 receptor expression differences (Hutchison et al., 2008). Thus, phenotypic abnormalities associated with rs9450898 observed in the current study may be
