cues only (Figure 2). Future studies will address whether a “direct” conversion between fibroblasts and neural progenitors is possible using neural transcription factors (Figure 2). Although this approach is intriguing, the efficiency of forming rosette-like colonies appeared low and the cells could not be expanded well. It remains to be seen what the communalities and differences of these indirect and direct iNPCs will be and whether such unstable pluripotent cells can also be generated from human fibroblasts.
