Studies comparing the predictive value and utility of different FH measures have largely examined their associations with behavioral phenotypes (e.g., tolerance, withdrawal, etc.) (Stoltenberg et al., 1998; Milne et al., 2013) and have mostly ignored their associations with endophenotypes. Endophenotypes are intermediate phenotypes on the putative causal pathway from genotype to phenotype (Euser et al., 2012). For example, low P3 amplitude, an ERP to a target of significance, has been considered as both a disease and vulnerability marker. Nevertheless, whether any differences exist in the associations between P3 amplitude and different variants of FH measures is not well-known. A comparative study of associations between different FH measures and P3 amplitude is important for the following reasons: 1) Reduced P3 is considered a biomarker of risk for developing AUD. There is substantial evidence that individuals with AUD, their unaffected offspring, and relatives manifest low P3 amplitude, particularly in multiplex AUD families compared to individuals with and without AUD from non-AUD families (Porjesz and Begleiter, 1996a; Porjesz et al., 1998; Begleiter et al., 1984; Berman et al., 1993; Hill and Steinhauer, 1993;
