with increased risk of colorectal cancer was associated with earlier time to tooth eruption, the allele associated with increased risk of breast cancer was associated with fewer teeth at 12 months. Expression of HMGA2 has been implicated in bladder and lung cancers (49,50). Expression of IGF II mRNA-binding protein produced by IGF2BP1 has been implicated in ovarian cancer (51). Furthermore, the pathway analysis implicated many pathways associated with cancer.