Rather than focusing on gene-lists, as was only possible in our prior analysis limited to the B6 and D2 strains, we used the power of genetic correlations across the BXD strains to derive coherent gene networks. Due to the complexity of this analysis and the importance of the PFC in influencing long-term adaptive responses to ethanol and goal-directed behavior [44], [45], [46], we restricted our network analysis to this brain region. A detailed analysis of network interactions across PFC, NAc and VMB will be presented elsewhere (Wolen and Miles, manuscript in preparation).
