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Chunk #13 — Materials and methods — Haplotype structure

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The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.
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Only two individuals were predicted to carry the*1A haplotype defined by the presence of A alleles at both rs4803381 (−1013) and rs61663607 (−745) (n= 85 haplotypes) and the major allele G at rs1137115, consistent with the reported rarity of this haplotype [24]. This haplotype, hence referred to as *1A(51G), was considered separately from the more common *1A(51A) allele in further analyses.