chronic alcoholic. In the current generation of HDID-1 mice, DID intakes are reduced when there is water available. However, if intakes continue to increase with further selection, we may well see significant intoxication in HDID-1 mice even when water is available. Maximal intakes are seen during the circadian dark, when feeding and drinking are normally highest. We do not know whether prandial drinking differs in significant ways from drinking at other times during the day, although one might suspect that some prandial drinking is motivated by feeding-associated thirst. Despite these limitations, the genes predisposing to high DID may well influence other alcohol-related traits; this remains to be demonstrated in future studies.
