Under strong assumptions about the effect sizes of rare variants, the slope of the LD Score regression can be re-scaled to be an estimate of the heritability explained by all SNPs used in the estimation of the LD Scores (Supplementary Table 1). Relaxing these assumptions in order to obtain a robust estimate of the heritability explained by all 1000 Genomes SNPs is a direction for further research; however, we note that the LD Score regression intercept is robust to these assumptions.
